Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway
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منابع مشابه
Role of Sonic hedgehog signaling pathway in neuroblastoma development
Malignant transformation of normal cells is a complex and accumulative process. Understanding this event gives insight into mechanisms of developmental biology and physical interaction of cellular machinery with surrounding ambient factors. However, the trend of embryonic malignancy is not interactive with ambient factors, rather a cause of deregulations of internal developmental process. In th...
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Introduction: Several reports have highlighted the role of Hh pathway activation in prostatecancer growth, but the relative contributions of autocrine and paracrine signaling remain unclear.Divergent reports of the presence or absence of autocrine signaling in established human prostatecancer cell lines has not clarified the matter.Materials and Methods: We comprehensively c...
متن کاملSonic Hedgehog Signaling in Limb Development
The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that Shh has the properties of the long sought after polarizing region morphogen that specifies positional values across the antero-posterior axis ...
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ژورنال
عنوان ژورنال: Oncogenesis
سال: 2014
ISSN: 2157-9024
DOI: 10.1038/oncsis.2014.10